ĭespite advances in early detection and treatment, CMM continues to be a disease with highly variable outcomes. These numbers raise concerns about optimizing the efficacy and the efficiency of CMM management, as well as the economic impact of this disease on healthcare systems. CMM is the third most common malignancy among Italians aged 50 years or less. In Italy, the estimated total number of new cases of cutaneous melanoma was 14,900 (8,100 in males, 6,700 in females) in 2020, while 169,900 people are estimated to be alive following a melanoma diagnosis. In the U.S., the median age at diagnosis is 65 years, and the median age at death from melanoma is 71 years. ![]() in 2021, and its incidence has been on a steady global increase over the past few decades. Melanoma accounted for 5.6% of all new cancer cases in the U.S. ![]() Cutaneous malignant melanoma (CMM) is one of the deadliest skin cancers due to its intrinsic biological aggressiveness and relatively high probability of misdiagnosis.
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